Arkuda Therapeutics

Arkuda Therapeutics is a biotechnology company applying new insights into lysosomal biology to drive the development of medicines to change the trajectory of neurodegenerative disease. Arkuda's lead program aims to correct progranulin deficiency and lysosomal dysfunction in GRN-related frontotemporal dementia (FTD-GRN), a genetically-defined subtype of frontotemporal dementia caused by an autosomal dominant mutation in the progranulin (GRN) gene. Beyond progranulin, Arkuda's compounds enhance the activity of several other key lysosomal enzymes, including beta-glucocerebrosidase (GCase), and the company is further exploring the therapeutic potential of its molecules in genetically-defined Parkinson's disease and other neurodegenerative diseases. Arkuda is backed by leading life science investors including Atlas Venture, Pfizer Ventures, funds managed by Tekla Capital Management LLC, and Mission BioCapital.